dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation

Hariharan, Manoj and Scaria, Vinod and Brahmachari, Samir K. (2009) dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation. BMC Bioinformatics, 10. ISSN 1471-2105

[img]
Preview
PDF (PubMed)
1471-2105-10-108.pdf - Published Version
Available under License Creative Commons Public Domain Dedication.

Download (775Kb) | Preview

Abstract

Background: MicroRNAs (miRNAs) regulate several biological processes through post- transcriptional gene silencing. The efficiency of binding of miRNAs to target transcripts depends on the sequence as well as intramolecular structure of the transcript. Single Nucleotide Polymorphisms (SNPs) can contribute to alterations in the structure of regions flanking them, thereby influencing the accessibility for miRNA binding.

Item Type: Article
Subjects: G Genome informatics > G1 Genome informatics (General)
Divisions: Faculty of Genome informatics and Structural Biology > School of Genome informatics
Depositing User: Raghu MV
Date Deposited: 27 Dec 2011 06:56
Last Modified: 27 Dec 2011 12:50
URI: http://openaccess.igib.res.in/id/eprint/88

Actions (login required)

View Item View Item