DyNAVacS: an integrative tool for optimized DNA vaccine design

Harish, Nagarajan and Gupta, Rekha and Aggerwal, Parul and Scaria, Vinod and Pillai, Beena (2006) DyNAVacS: an integrative tool for optimized DNA vaccine design. PubMed, 34. W264-W266. ISSN 1362-4962

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Abstract

DNA vaccines have slowly emerged as keystones in preventive immunology due to their versatility in inducing both cell-mediated as well as humoral immune responses. The design of an efficient DNA vaccine, involves choice of a suitable expression vector, ensuring optimal expression by codon optimization, engineering CpG motifs for enhancing immune responses and providing additional sequence signals for efficient translation. DyNAVacS is a web-based tool created for rapid and easy design of DNA vaccines. It follows a step-wise design flow, which guides the user through the various sequential steps in the design of the vaccine. Further, it allows restriction enzyme mapping, design of primers spanning user specified sequences and provides information regarding the vectors currently used for generation of DNA vaccines. The web version uses Apache HTTP server. The interface was written in HTML and utilizes the Common Gateway Interface scripts written in PERL for functionality. DyNAVacS is an integrated tool consisting of user-friendly programs, which require minimal information from the user. The software is available free of cost, as a web based application at URL: http://miracle.igib.res.in/dynavac/.

Item Type: Article
Subjects: G Genome informatics > G1 Genome informatics (General)
Divisions: Faculty of Genome informatics and Structural Biology > School of Genome informatics
Depositing User: Raghu MV
Date Deposited: 26 Dec 2011 13:09
Last Modified: 27 Dec 2011 12:46
URI: http://openaccess.igib.res.in/id/eprint/86

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