Conformational Flexibility May Explain Multiple Cellular Roles of PEST Motifs

Sandhu, Kuljeet Singh and Dash, Debasis (2006) Conformational Flexibility May Explain Multiple Cellular Roles of PEST Motifs. Conformational flexibility may explain multiple cellular roles of PEST motifs, 63 (4). pp. 727-732.

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Abstract

PEST sequences are one of the major motifs that serve as signal for the protein degradation and are also involved in various cellular processes such as phosphorylation and protein-protein interaction. In our earlier study, we found that these motifs contribute largely to eukaryotic protein disorder. This observation led us to evaluate their conformational variability in the nonredundant Protein Data Bank (PDB) structures. For this purpose, crystallographic temperature factors, structural alignment of multiple NMR models, and dihedral angle order parameters have been used in this study. The study has revealed the hypermobility of PEST motifs as compared to other regions of the protein. Conformational flexibility may allow them to participate in number of molecular interactions under different conditions. This analysis may explain the role of protein backbone flexibility in bringing about multiple cellular roles of PEST motifs.

Item Type: Article
Subjects: BI Bioinformatics > BI1 Bioinformatics (General)
Divisions: Faculty of Genomics and Molecular Medicine > School of Genomics and Molecular Medicine
Depositing User: Raghu MV
Date Deposited: 17 Jan 2012 11:49
Last Modified: 17 Jan 2012 11:49
URI: http://openaccess.igib.res.in/id/eprint/126

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