Role of Intrinsic Disorder in Transient Interactions of Hub Proteins

Singh , Gajinder Pal and Ganapathi, Mythily and Dash, Debasis (2006) Role of Intrinsic Disorder in Transient Interactions of Hub Proteins. Role of Intrinsic Disorder in Transient Interactions of Hub Proteins, 66 (4). pp. 761-765.

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Abstract

Hubs in the protein-protein interaction network have been classified as "party" hubs, which are highly correlated in their mRNA expression with their partners while "date" hubs show lesser correlation. In this study, we explored the role of intrinsic disorder in date and party hub interactions. The data reveals that intrinsic disorder is significantly enriched in date hub proteins when compared with party hub proteins. Intrinsic disorder has been largely implicated in transient binding interactions. The disorder to order transition, which occurs during binding interactions in disordered regions, renders the interaction highly reversible while maintaining the high specificity. The enrichment of intrinsic disorder in date hubs may facilitate transient interactions, which might be required for date hubs to interact with different partners at different times.

Item Type: Article
Subjects: BI Bioinformatics > BI1 Bioinformatics (General)
Divisions: Faculty of Genomics and Molecular Medicine > School of Genomics and Molecular Medicine
Depositing User: Raghu MV
Date Deposited: 17 Jan 2012 09:56
Last Modified: 08 Feb 2013 10:08
URI: http://openaccess.igib.res.in/id/eprint/117

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