MicroRNAs: novel therapeutic targets in neurodegenerative diseases

Roshan, Reema and Ghosh, Tanay and Scaria, Vinod and Pillai, Beena (2009) MicroRNAs: novel therapeutic targets in neurodegenerative diseases. MicroRNAs: novel therapeutic targets in neurodegenerative diseases, 14 (23/24). pp. 1123-1129.

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Abstract

The prevalence of neurodegenerative disorders is rising steadily as human life expectancy increases. However, limited knowledge of the molecular basis of disease pathogenesis is a major hurdle in the identification of drug targets and development of therapeutic strategies for these largely incurable disorders. Recently, differential expression of endogenous regulatory small RNAs, known as ‘microRNAs’ (miRNAs), in patients of Alzheimer's disease, Parkinson's disease and models of ataxia suggest that they might have key regulatory roles in neurodegeneration. miRNAs that can target known mediators of neurodegeneration offer potential therapeutic targets. Our bioinformatic analysis suggests novel miRNA–target interactions that could potentially influence neurodegeneration. The recent development of molecules that alter miRNA expression promises valuable tools that will enhance the therapeutic potential of miRNAs.

Item Type: Article
Subjects: G Genome informatics > G1 Genome informatics (General)
Divisions: Faculty of Genome informatics and Structural Biology > School of Genome informatics
Depositing User: Raghu MV
Date Deposited: 28 Dec 2011 05:30
Last Modified: 08 Feb 2013 10:15
URI: http://openaccess.igib.res.in/id/eprint/107

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